Convergent synthesis of the tetrasaccharide repeating unit of the O-antigen of Shigella boydii type 9

• Abhishek Santra and
• Anup Kumar Misra

Beilstein J. Org. Chem. 2011, 7, 1182–1188, doi:10.3762/bjoc.7.137

• Abhishek Santra Anup Kumar Misra Bose Institute, Division of Molecular Medicine, P-1/12, C.I.T. Scheme VII-M, Kolkata-700054, India; Fax: 91-33-2355 3886 10.3762/bjoc.7.137 Abstract A convenient synthesis of the tetrasaccharide repeating unit of the O-antigen of Shigella boydii type 9 has been

• glycoside in high yield. Keywords: diarrhea; glycosylation; O-antigen; oligosaccharide; Shigella boydii; Introduction Diarrhoeal disease is a common cause of death in the tropical countries and it is the second mostly causing infant deaths worldwide. Shigella is one of the well-studied human pathogens

• that cause diarrhoeal disease and dysentery (e.g., shigellosis). Among several types of Shigella species, Shigella dysenteriae is the most virulent pathogen causing devastating health problems in developing countries [1][2][3]. Shigella strains are classified into four species: Shigella boydii